An informational speech on Gatorade.

An informational speech on Gatorade. Water will not replace all the ingredients of sweat. Tonight I will inform you about Gatorade and the benefits of drinking it while exercising. You're probably asking yourself "Why should I care about Gatorade while exercising?" and the answer to that is dehydration. Dehydration is defined as the excessive loss of body fluid. First I will give you a history of Gatorade, 2nd I will tell you what Gatorade is, then I will explain how Gatorade works, and finally I will compare Gatorade against other sports drinks on the market.Deep in Florida Gator country dehydration was a major problem. The University started to research on an "alternative to water" and Gatorade was created by Dr. Robert Cade and Dr. Dana Shires in 1966 at the University of Florida and named Gatorade after the University's football team, the gators. A year later after Dr. Cade made an agreement with Stokely-Van Camp to market Gatorade, which he already patented.GatoradeThe Florida Gators used it in 1967 for the first t ime. It was also the first time they won the Orange Bowl title beating Georgia Tech. During an interview with the Georgia Tech head coach a reporter asked why they lost. The head coach replied "Because we did not have Gatorade on our sidelines." In 1969 the Kansas City Chiefs used the sports drink an attribute their Super Bowl victory that year to Gatorade. Only one year after its commercial introduction, Gatorade reformulated its recipe due to the Food and Drug Administration banned Sodium Cyclamate, which is a sweetener, according to Gatorade.com, last accessed on October 9, 2005. The Quaker Oats company bought Stokely Van-Camp in 1983 and licensed marketing rights to Pepsi co. until 2001 when Pepsi Co. bought the Quaker Oats Company, according to wikipedia.com, last accessed on October...

Idioms and Expressions in Context

Idioms and Expressions in Context Its important to learn and use idioms and expressions in context. Of course, idioms are not always easy to understand. There are idiom and expression resources that can help with definitions, but reading them in short stories can also provide context that makes them come more alive. Try reading the story one time to understand the gist without using the idiom definitions. On your second reading, use the definitions to help you understand the text while learning new idioms. After you understand the story, take the quiz at the end of each reading to test your knowledge. Teachers can print out these short stories and use in class in combination with teaching ideas provided at the end of this resource list. Idioms and Expressions in Context Stories Johns Keys to SuccessA story about a man was an accomplished businessman and happily gives advice to young people he mentors. Odd Man OutA story about a man who gossiped a little too much at parties making him the odd man out anytime he joined the fun. Young and FreeA short story about what it takes to be successful in a small company. Its good preparation for young adult English learners who are college age. My Successful FriendHere is a story about a mans friend who has had a very successful career. The Road to SuccessHere is a short essay on how to succeed in todays difficult economic environment. It makes good reading for business English classes. For Teachers Use these idioms in context stories with your advanced-level classes to provide context for learning common idioms in English. Each short story of two to three paragraphs provides approximately 15 idioms. These idioms are then defined following the story followed by a short quiz testing a number of idioms from the selection. Following this introduction to the idioms in context, you can practice use of the idioms in a number of ways. Here are a few ideas: Ask students to write their own short stories using the idioms in context.Have students write dialogues using the idioms to act out in class.Group students together to create their own gap fill quizzes for other groups.Write up questions using the idioms presented and discuss as a class or in groups.Make up situations that fit each idiom on-the-fly and ask students to choose the idiom that fits best. Learning Idioms in Context   You might wonder how you can recognize an idiom when you are reading a book, online or perhaps watching TV. Here are a few tips on how you can spot an idiom: Idioms dont actually mean what they say. Thats right, the actual meaning of the words dont necessarily indicate the meaning of the idiom. Lets take a look at a few: Remember my son, the early bird catches the worm.   This idiom means that its important to get up and get to work in order to succeed in life. Of course, early birds probably catch worms as well! However, the meaning has nothing to little to do with the words.   Idioms can seem out of context. You can be sure youve spotted an idiom if you notice that the words have little to do with the context. For example, lets imagine that youre in a business meeting. Someone says: Well, itll be smooth sailing after this quarter. If youre in a business meeting, you dont expect to be talking about sailing on the open sea. This is an example of something out of context. It doesnt fit in. Thats a sure sign that it might be an idiom.   Idioms are often phrasal verbs. Phrasal verbs can be literal or figurative. Literal means that the words mean exactly what they say. For example: I picked up the bag. In this case. pick up is literal. Phrasal verbs, can also be figurative pick up also means to learn: She picked up some Spanish in Madrid.   Idioms are often figurative phrasal verbs as well. Use these queues and youll start recognizing idioms in context everywhere you look and listen.

Total quality management Essay Example | Topics and Well Written Essays - 6000 words

Total quality management - Essay Example In such a setup, all members of the organisations are trained and motivated to work towards improving processes, products and services offered by the organisation and based on the cultivation of a positive culture (Bagad, 2008, p.31). Oman Air is one of the leading airline companies in the Oman that have continued to grow and advance due to its great customer service focus and market centrality. The company currently operates large flights of planes plying different routes across the globe and offering unique and admirable services to the customers. The admirable service delivery approach has been attributed to the company’s adoption of a proper TQM that seeks to improve its customer relations and increase overall customer satisfaction (Flynn, 2011, p13). According to this introduction, the essay is organised as the following: First, it will critically evaluate the perception of Leadership role in quality management at Oman airline and how it can differ from one context to another. Second, it will highlight the different models for delivering good total quality management. After that, it will attempt to explore the role of teamwork, Customer satisfaction, Culture of improvement and risk management in total quality management of that will lead to better applications in total quality management in all organisations contexts. Finally, it will sum up the main points. The success of quality management in an organisation depends on the leadership approach adopted by the management and this approach is communicated to the other employees in the organisation. Leadership plays an essential management role in the implementation of TQM in any organisation due to the two benefits that it confers. Through leadership, Oman Air has enhanced its ability to mould its philosophy and principles within the various departments, which serves to improve the

Compare and contrast the difference between a psychotherapy threatment Literature review

Compare and contrast the difference between a psychotherapy threatment and religion - Literature review Example However, the psychotherapy treatment intervention is highly based on the psychologist’s dealing with the clients by stating them their level of independent competencies required for coping. Moreover, psychotherapy treatment involves various theoretical methods as well as the behavioural assessments of the patients. Nevertheless, in religious therapy, intervention plan is highly dependent upon the patient’s willingness to cope with health disparities, difficulties, and sacrifice (DeRubeis & et. al., 2008). Correspondingly, the approach of psychotherapy treatment mechanism is regarded as the process, which works on developing interpersonal interventions to mitigate the mental health problems of the patient. Besides, the approach of the treatment helps to develop the social well-being of the client in the most effective and rapid manner and reduce the discomfort that they face. Moreover, during the course of treatment, practitioners utilise various techniques, which is based on enriching the relationship as well as the communication and changing the behaviour that will likely contribute to improve the mental state of the patient. Similarly, intervention of the therapy is highly based on the problem of the patient, as some of the therapy highly focuses on changing their current behaviour whereas, other mechanisms emphasise over determining the previous issues and resolving the existing problems. Nevertheless, the approach of psychotherapy treatment undertakes mental health issues includi ng bulimia, depression, anger management, anxiety, phobias and chronic pain among others (Ritchey & et. al., 2011; Combs & Romm, n.d.). Apparently, the means of religion therapy treatment also plays an integral role to eradicate the issue of patient conditions and prove to be effective as a form of therapy. It is in this context that the means of

Basic Concept Of Coordination Compounds Biology Essay

Basic Concept Of Coordination Compounds Biology Essay We live in the world of uncertainty and assumptions, no one can predict the next activity, it may be good or bad but thing is how to tackle bad things? Chemistry is the most power full tool to understand the world at almost every scale may be huge or femtometer scale. Chemistry is closely associated with humans day to day life , it application in medicine is major one. Medicine is the life living entity which play vital role in ones life , but how medicines are made? What are their chemical properties and how they affect our body? Let us study the application of chemistry(co-ordination compounds) in medicinesà ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦. Basic concept of co-ordination compoundsà ¢Ã¢â€š ¬Ã‚ ¦Ãƒ ¢Ã¢â€š ¬Ã‚ ¦ The coordination chemistry was discovered by Nobel Prize winner Alfred Werner (1866-1919). He received the Nobel Prize in 1913 for his coordination theory of transition metal-amine complexes. In the starting of the 20th century, inorganic chemistry was not a prominent field until Werner studied the metal-amine complexes such as [Co (NH3)6Cl3]. He further studied the coordination compound of cobalt and ammonia and discovered its different properties. He studied different colors and no. of Cl atoms attached to the compounds and on that basis he proposed a table- Solid Color Ionized Cl- Complex formula CoCl36NH3 Yellow 3 [Co(NH3)6]Cl3 CoCl35NH3 Purple 2 [Co(NH3)5Cl]Cl2 CoCl34NH3 Green 1 trans-[Co(NH3)4Cl2]Cl CoCl34NH3 Violet 1 cis-[Co(NH3)4Cl2]Cl The structures of the complexes were proposed based on a coordination sphere of 6. The 6 ligands can be amonia molecules or chloride ions. Two different structures were proposed for the last two compounds, the trans compound has two chloride ions on opposit vertices of an octahedral, whereas the the two chloride ions are adjacent to each other in the cis compound. The cis and trans compounds are known as geometric isomers. Other cobalt complexes studied by Werner are also interesting. It has been predicted that the complex Co(NH2CH2CH2NH2)2ClNH3]2+ should exist in two forms, which are mirror images of each other. Werner isolated solids of the two forms, and structural studies confirmed his interpretations. The ligand NH2CH2CH2NH2 is ethylenediamine (en) often represented by en. Basically coordination compound consists of two parts Central metal ion Ligands both metal ion and ligands lie inside or outside the coordination sphere, coordination sphere is represented by square brackets for example [Co(NH3)6]Cl3 here Co is the metal ion and NH3,Cl3 are the ligands , one lie inside and the second one is outside. Contain coordinate covalent bonds 4) Unusual composition: Central metal ion or atom + ligands + counter ion (if needed) 5) Called complex ion if charged For an instantÆ’Â   Basic concept of medicines and how they are discovered Drug discovery is very time -consuming and expensive process. Estimates of the average time required to bring a drug to a market ranges from 12-15 years at an average cost of $600-800 million. For approximation every 10,000 compounds are evaluated in animal studied , 10 will make it to humans clinical trials in order to get 1 compound on the market ! for every drug introduction we need approval for that and once the new drug application (NDA) is submitted to the Food and Drug Administration(FDA) , it can be several months to several years before it is approved for commercial use. Then study is done and the result are considered and if the results are found are same with the drug that is already in the market then the whole project is rejected ! so the discovery of new medicine is very costly , that is why medicines costs high when bought. In general medicines are never discovered , what is more likely discovered is called lead compound. The lead compound is prototype compound that has a number of attractive characteristics , such as the desired biological but may have many undesired characteristics for example high toxicity ,other biological activities, absorption difficulty ,insolubility or metabolism problems , so considering all these things further modified compound is formed which is called clinical drug ,which is ready for many clinical researches. The drug discovered without lead are called penicillins ! How does a medicine works on human body? The quest for knowledge to established how the drug act in a living system has been a thought provoking topic to scientist belonging to various disciplines such as medicinal chemistry, biochemistry and pharmacology. Factors affecting the drugs to reach the active sites Absorption-biological membrane play a vital role towards the absorption of a drug molecule. Soon after drug is taken orally ,it makes the way through the gastrointestinal tract, cross the various membranes and finally reaches the active site. It has been observed that drug moves from a region of high drug concentration to low drug concentration. However the rate of diffusion solely depends upon the magnitude of the concentration gradient (à ¢Ã‹â€ Ã¢â‚¬  C). across the biological membrane. Rate = -k{C(abs) C(bl)}, c(bl) is concentration present in blood and C(abs) is the concentration of drug at active site. Distribution As soon as drug finds its way into the blood stream, it tries to approach the site of biological action. Hence , the distribution of a drug is markedly influenced by such vital factor as tissue distribution and membrane penetration ,which largely depends on the physio-chemical characteristics of the drug. Metabolism (biotransformation)-when a drug molecule gets converted into the body to an altogether different form, the phenomenon is called biotransformation. Mostly the metabolism occurs in the liver. The metabolism products are more polar than the parent drug. Inside liver ,in metabolism two important reactions take Change in the functional groupeg. The side chain or ring hydroxylation reduction of nitrogroup. Conjugationthe drug substance undergoes conjugation whereby the metabolized product combines with various solubilizing groups. Excretion this is also very important process and may be done with the help of a number of process ,namely renal excretion, biliary excretion , excretion through lungs and above all by drug metabolism(biotransformation). COMMON TYPES OF MEDICINES USED IN DAILY LIFE Some of the medicines which we use in daily life are:Æ’Â   CISPLATINtreatment of cancer Paracetamol -reduces body temp. Aspirin reduces pain Local anesthetic 1 )Cisplatin :- Cisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often considered an alkylating agent, it contains no alkyls groups and does not instigate alkylating reactions, so it is properly designated as an alkylating-like drug. Cisplatin is platinum-based and was the first medicine developed in that drug class. Other drugs in this class include carboplatin, a drug with fewer and less severe side effects introduced in the 1980s, and oxaliplatin, a drug which is part of the FOLFOX treatment for colorectal cancer. The other names for cisplatin are DDP, cisplatinum, and cis-diamminedichloridoplatinum(II) (CDDP). Cisplatin was actually first created in the mid 19th Century and is also known as Peyrones chloride. (The disoverer was Michel Peyrone.) It wasnt until the 1960s that scientists started getting interested in its biological effects, and cisplatin went ito clinical trials for cancer therapy in 1971. By the late 1970s it was already widely used and is still used today despite the many newer chemotherapy drugs developed over the past decades. Structure of cisplatin:- Structure of cisplatin is tetrahydral (sp3) in shape. Here one atom of platinum is bound to 2 chlorine atoms and 2 ammonia atoms. Working mechanism of cisplatin:- The way that cisplatin operates is by forming a platinum complex inside of a cell which binds to DNA and cross-links DNA. When DNA is cross-linked in this manner, it causes the cells to undergo apoptosis, or systematic cell death. One of the methods it uses causes apoptosis through cross-linking is by damaging the DNA so that the repair mechanisms for DNA are activated, and once the repair mechanisms are activated and the cells are found to not be salvageable, the death of those cells is triggered instead. Cisplatin undergoes aquation to form [Pt(NH3)2Cl(OH2)]+ and [Pt(NH3)2(OH2)2]2+ once inside the cell. The platinum atom of cisplatin binds covalently to the N7 position of purines to form 1,2- or 1,3-intrastrand crosslinks, and interstrand crosslinks. Cisplatin-DNA adducts cause various cellular responses, such as replication arrest, transcription inhibition, cell-cycle arrest, DNA repair and apoptosis. 2 ParacetamolÆ’Â   Paracetamol is commonly used for relief in headache , and other minor pain and aches. It also serve as major ingredient in cold and flu remedies in collaboration with opioid analgesics, it can also be used in management of several major disease such as cancer. Structure of paracetamolÆ’Â   In some publications, it is described as 4-hydroxyacetanilide or N-acetyl-p-aminophenol and in the US Pharmacopoeia it is known as acetaminophen. Paracetamol is a white, odourless crystalline powder with a bitter taste, soluble in 70 parts of water (1 in 20 boiling water), 7 parts of alcohol (95%), 13 parts of acetone, 40 parts of glycerol, 9 parts of propylene glycol, 50 parts of chloroform, or 10 parts of methyl alcohol. It is also soluble in solutions of alkali hydroxides. It is insoluble in benzene and ether. A saturated aqueous solution has a pH of about 6 and is stable (half-life over 20 years) but stability decreases in acid or alkaline conditions, the paracetamol being slowly broken down into acetic acid and p-aminophenol. Mixtures of paracetamol and aspirin are stable in dry conditions, but tablets containing these two ingredients, particularly in the presence of moisture, magnesium stearate, or codeine, produce some diacetyl-p- aminophenol when stored at room temperature, and this latter compound is hydrolyzed in the presence of moisture to paracetamol and p-aminophenol. Mechanism of workingÆ’Â   Over 100 years after it was first discovered, we are now learning what the mechanism of action is that makes paracetamol such an effective and useful medicine. It now appears paracetamol has a highly targeted action in the brain, blocking an enzyme involved in the transmission of pain. As with many medicines, the effectiveness of paracetamol was discovered without knowing how it works. Its mode of action was known to be different to other pain relievers, but although it produces pain relief throughout the body the exact mechanism was not clear. The production of prostaglandins is part of the bodys inflammatory response to injury, and inhibition of prostaglandin production around the body by blocking the cyclooxygenase enzymes known as COX-1 and COX-2 has long been known to be the mechanism of action of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen. However, their action in blocking COX-1 is known to be responsible for also causing the unwanted gastrointestinal side effects associated with these drugs. Paracetamol has no significant action on COX-1 and COX-2, which left its mode of action a mystery but did explain its lack of anti-inflammatory action and also, more importantly, its freedom from gastrointestinal side effects typical of NSAIDs. Early work (1) had suggested that the fever reducing action of paracetamol was due to activity in the brain while its lack of any clinically useful anti-inflammatory action was consistent with a lack of prostaglandin inhibition peripherally in the body. Now, recent research (2) has shown the presence of a new, previously unknown cyclooxygenase enzyme COX-3, found in the brain and spinal cord, which is selectively inhibited by paracetamol, and is distinct from the two already known cyclooxygenase enzymes COX-1 and COX-2. It is now believed that this selective inhibition of the enzyme COX-3 in the brain and spinal cord explains the effectiveness of paracetamol in relieving pain and reducing fever without having unwanted gastrointestinal side effects. 3 Aspirin In 1897 Flex Hoffman a German chemist employed by bayer and company was researching on the arthritic pain of his father ,then he began his study on the acetalsalicyclic acid and discovered a stable compound which was further refined to Aspirin ! Acetylsalicylic acid, marketed everywhere as Aspirin (USAN), is a salicylate drug mostly used as an antipyretic to reduce fever, as an anti-inflammatory medication to reduce swelling, and as an analgesic to alleviate minor pains and aches. To wit, aspirin is often used to relieve mild to moderate pain and to reduce fever from typical maladies such as headaches, toothaches, muscle aches, and the common cold. This medication may also be used to reduce arthritic swelling and pain as well. This salicytate drug is classified as a nonsteroidal anti-inflammatory drug or NSAID, and it works by blocking a certain natural substance in your body to reduce inflammation and throbbing aches. Structure of AspirinÆ’Â   Aspirin, also known as acetylsalicylic acid, has a chemical formula of C9H8O4. Working mechanism of aspirin:- Many kinds of prostaglandin exist in the body to serve a plethora of physiological functions, some of which are irritable, others beneficial.   Prostaglandins are among the chemicals secreted by the bodys immune system when it fights off bacteria and other invaders in injuries.   Located around wounds , these chemicals cause pain and inflammation.   Following bacterial infection, prostaglandins are also produced the hypothalamus, the brains center for controlling body temperature, resulting in a rise in temperature.   In their capacities to cause pain, inflammation, and fever, prostaglandins are nuisances.   Inhibiting their production, consequently reducing pain, inflammation, and fever, is the main therapeutic value of aspirin. On the other hand, prostaglandins secreted by the stomach regulate acid production and maintain the mucus lining that protects the stomach from digesting itself.   Prostaglandins in the bloods platelets cause the platelets to stick together to initiate blood clotting in wounds.   In these capacities, prostaglandins are crucial to a healthy body.   Inhibiting their production leads to aspirins undesirable side effects, including upset stomach and excessive bleeding.   How does aspirin curb prostaglandin production?   The many kinds of prostaglandin are synthesized by a host of complicated biochemical pathways.   However, all pathways share a common stage facilitated by an enzyme called COX, whose action aspirin suppresses.  Ã‚   Enzymes are protein catalysts that speed up chemical reactions without being themselves used up in the reactions.   An enzyme is a huge molecule with an active area that works somehow like a mold that accepts certain raw pieces and casts them into a final form.   Imagine a mold that stamps a rod and a bowl into a spoon.   Spoon production would be disrupted if someone throws a monkey range into the mold.   Such a monkey range an enzyme inhibitor would make a desirable drug if it stops an enzyme from producing disease-inducing chemicals.   Aspirin is an enzyme inhibitor.   It suppresses the action of the enzyme COX, stops the production of prostaglandin, thus disrupting the pathways to pain, inflammation, elevated temperature, and stomach protection.   Vanes success attracted many researchers to the area.   Their investigations spread from aspirin to similar drugs that suppress pain and inflammation.   By 1974, it was fairly well established that all NSAIDs act with similar mechanisms.   They are all COX inhibitors. Aspirin, ibuprofen, naproxen, and many other non-steroidal anti-inflammatory drugs (NSAIDs) work as COX inhibitors.   They suppress the catalytic functions of the enzymes COX1 and COX2.   COX2, which appears up injuries and other inflammatory stimuli, is deemed bad.   It catalyzes the synthesis of prostaglandins that, located near sites of injuries, cause pain and inflammation.   Inhibition of COX2 is responsible for the therapeutic effects of reducing pain, inflammation, and fever.   COX1, which is present in many parts of the body, is deemed good.   It catalyzes the synthesis of prostaglandins that perform many physiological functions, e.g., maintaining the mucus lining of the stomach or causing platelets in the blood to stick and form clots over wounds.   Inhibition of COX1 is responsible for the drugs side effect of stomach irritation.   In reducing the risk of blood clots, it is also responsible for aspirins efficacy in heart attack prevention.   A new class of NSAID, COX2 inhibitor, is designed to target bad COX2 selectively and leave good COX1 alone, thus reducing pain and inflammation without upsetting the stomach. 4-local anestheticÆ’Â   Cocaine is a naturally occurring compound indigenous to the AndesMountains, West Indies, and Java. It was the first anesthetic to be discovered and is the only naturally occurring local anesthetic; all others are synthetically derived. Cocaine  was introduced into Europe in the 1800s following its isolation from coca beans. Sigmund Freud, the noted Austrian psychoanalyst, used cocaine on his patients and became addicted through self-experimentation. In the latter half of the 1800s, interest in the drug became widespread, and many of cocaines pharmacologic actions and adverse effects were elucidated during this time. In the 1880s, Koller introduced cocaine to the field of ophthalmology, and Hall introduced it to dentistry. Halsted was the first to report the use of cocaine for nerve blocks in the United States in 1885 and also became addicted to the drug through self-experimentation. Procaine, the first synthetic derivative of cocaine, was developed in 1904. Lofgren later developed lidocaine, the most widely used cocaine derivative, during World War II in 1943. Chemical structureÆ’Â   All local anesthetics have an intermediate chain linking an amine on one end to an aromatic ring on the other. The amine end is hydrophilic, and the aromatic end is lipophilic. Variation of the amine or aromatic ends changes the chemical activity of the drug. Two basic classes of local anesthetics exist, the amino amides and the amino esters. Amino amides have an amide link between the intermediate chain and the aromatic end, whereas amino esters have an ester link between the intermediate chain and the aromatic end. Amino esters and amino amides differ in several respects. Amino esters are metabolized in the plasma via pseudocholinesterases, whereas amino amides are metabolized in the liver. Amino esters are unstable in solution, but amino amides are very stable in solution. Amino esters are much more likely than amino amides to cause  allergic hypersensitivity reactions. Commonly used amino amides include lidocaine, mepivacaine, prilocaine, bupivacaine, etidocaine, and ropivacaine and levobupivacaine. Commonly used amino esters include cocaine, procaine, tetracaine,  chloroprocaine,  and benzocaine. An easy way to remember which drug belongs in which category is that all of the amino amides contain the letter i twice, as does the term amino amides. The newest additions to clinically available local anesthetics, namely ropivacaine and levobupivacaine, represent exploitation of the S enantiomer of these chemicals to create anesthetics which are less toxic, more potent, and longer acting. WORKINGÆ’Â   Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by anesthetics reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. When a nerve loses depolarization and capacity to propagate an impulse, the individual loses sensation in the area supplied by the nerve.   The order of affinity of local anesthetics for different sodium channel states is open is better than inactivated, which is better than resting.  Thus, the  open state of the sodium channel is the primary target of local anesthetic molecules.  The blocking of propagated action potentials is therefore a function of the frequency of depolarization. The mechanism for differential block, the block of pain perception without motor block, is  still unclear.   *

Ambiguities in the Textual Body of The Castle of Otranto Essay

Incongruous Corpus: Ambiguities in the Textual Body of The Castle of Otranto While the relationship of the Gothic to the Romantic is debatable, the persistent desire of some critics to see it as pre-Romantic should not disguise the possibility that the genre is â€Å"actually sending out very contradictory impulses about its own intentions, [and] adopting certain strategies that thwart the very perceptions it seems to be on the brink of achieving† (Napier, 4). This uncertainty in form and intent has produced imprecision and imbalances in Gothic novels that are partly the result of instability within the Gothic form. Although the Gothic achieves stability by repeating a certain pattern of accepted conventions, leading to remarkable coherence in the â€Å"routine likeness of one romance to another† (Napier, 4), one must be mindful that the Gothic is â€Å"formally and stylistically marked by disequilibrium† (Napier, 4). The imbalance, dissolution, and formal unevenness of the Gothic genre, which some scholars claim are recurrent issues with in the genre, are found as early as the first Gothic novel in The Castle of Otranto. Their existence in Otranto suggests the profound uncertainty Walpole had about the intent of the genre as he perceived it and hints at the immense task the author faced in establishing a new genre that required the â€Å"difficult and uneven breaking away from the more carefully structured and considered narratives of the preceding period† (Napier, 5). Walpole’s inability to provide a thorough theoretical explanation of the intent of the genre and breakaway cleanly from pre-existing narrative norms accounts, in part, for the presence of tonal and modal incongruities within the textual body of Otranto. An examination of the theo... .... Meaning is deflected to surfaces and nothing about a character is truly known beyond what is necessary to further the plot. Nonetheless, despite all the structural incongruities within the body of Otranto, Walpole was successful in establishing a genre that later practitioners perfected. Works Cited Clery, E. J. Introduction. The Castle of Otranto. By Horace Walpole. New York: OUP, 1998. vii-xxxiii. Kiely, Robert. The Romantic Novel in England. Cambridge, Mass.: Harvard UP, 1972. Mowl, Tim. Horace Walpole: The Great Outsider. London: John Murray (Publishers) Ltd., 1996. Napier, Elizabeth R. The Failure of Gothic: Problems of Disjunction in an Eighteenth-Century Literary Form. New York: OUP, 1987. Sedgwick, Eve K. Coherence of Gothic Conventions. New York and London: Methuen, 1986. Walpole, Horace. The Castle of Otranto. New York: OUP, 1998.

Legislative Requirements Essay

The purpose of this assignment is to identify the key aspects of current legislative requirements and codes of practice for teaching within the animal care sector. As a teacher within the establishment, it is my responsibility to ensure that none of my students are disadvantaged, by taking into account the Equal opportunity legislation, formally known as the Equality Act 2010, which came into force on the 6th October. It states that â€Å"no one is to be discriminated against irrespective of age, ethnic origin, gender, race, nationality, disability or domestic circumstances† the Equality act also replaces the Disability discrimination act. It would be my responsibility as a teacher, to ensure that any resources such as handouts and other learning material are free from bias (Wilson 2008 Pg 21 chap 1). Being in part, a vocational course, the health and safety at work act 1974 would be a key legislative requirement, as an educator I would be expected to demonstrate a model of best practice for my students to look up to and follow, subsequently, The management of Health and safety at work regulations 1999 would also be another piece of legislation which would be particulary relevant Furthermore, as an educator by law I have a duty of care towards my students, the legislation states that as teachers if you are proven negligent, you may have to compensate the injured party, not only does this apply to individuals but the organisation as well, I would have to ensure that whilst providing learners the opportunity to experiment and develop independence, it would have to be achieved in a safe working environment. Reporting of injuries diseases and dangerous occurrences 1995 is also relevant, being an educator in a potentially hazardous environment, more commonly known as RIDDOR, and states that certain incidents are reportable by law, they must be reported to the health and safety executive and the local authority, An example of this being if hospital treatment is needed to be administered to a student following an activity, the educational establishment should have clear guidelines on how to report incidents. There are numerous legislative requirements which as an educator I would have to adhere to. Wilson (2008) states that whilst some of these aspects need only awareness of context, many of them will impact on your first teaching experience, therefore require a detailed knowledge.